Rupted in mice, osteoblasts exhibit a blunted Egr2 mRNA expression in response to mechanical strain [43]. Taken together, more research is required in order to elucidate the role ER plays in EGR2 regulation. TGF- and Wnt signaling regulate a variety of physiological processes including mammary gland developmentand tumorigenesis. SFRP1 has been associated with the control of TGF- and Wnt signaling.