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Ptide absorbed to CAP was consistent with an -helix, whereas when bound to HA the structure corresponded more to a random coil [107]. We studied DPP peptides by FTIR spectroscopy and found the phosphorylated peptides in solution in the presence of HA formed -helical structures and lost their random coil characteristics [108]. Perhaps, through evolution, the most efficient strategy found by nature
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Riments performed in duplicate and normalized to the amplification of ACTB mRNA. Bars represent mean ?SEM of the fold change with respect to untreated. *p
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Ased on NETPHOS software. We also includeAuthor Manuscript Author Manuscript Author Manuscript Author ManuscriptMatrix Biol. Author manuscript; available in PMC 2017 May 01.Boskey and Villarreal-RamirezPageSPARC (osteonectin), a protein involved with mineralization (linked in some ways to osteoporosis) that has some IDP regions. The SIBLINGs all bind to HA, however characterizing adsorption of pro
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